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Glossary Abbreviations 7-HMG 7-hydroxymitragynine T 1/2 half-life LC-HRMS liquid chromatography high-resolution mass spectrometry TLC thin-layer chromatography HPLC high-performance liquid chromatography CYP3A4 cytochrome P450 3A4 NMR nuclear magnetic resonance MRM multiple reaction monitoring mode

For acute tendon or ligament injuries, typical anecdotal protocols suggest 250mcg to 500mcg twice daily, often administered near the site of injury for localized effect, though systemic routes are also used

Some patients may experience numbness or lumpiness that can persist for four to six weeks or longer

The compound is not scheduled under the Controlled Substances Act and is not explicitly banned but it also lacks FDA approval and has no place on the 503A Bulk Drug Substances List, which is the only pathway for licensed compounding pharmacies to legally dispense it