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Christine Ladd-Acosta, vice director of the Wendy Klagg Center for Autism at John Hopkins

Edlind and Katiyar, 2022)

Here, we present compelling results demonstrating a functional connection between altered TrkB signalling in iSPNs and changes in glutathione metabolism, particularly the enzyme GSTO2, at the pre-symptomatic stage, causing an early increase in DA followed by progressive degeneration and the onset of hyperkinetic symptoms