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a) Cell cultures exposed to low glucose levels (0.1 mM glucose) and high glucose levels (25 mM glucose) were combined

2.2 PBPK models development and verification PBPK models for 13 drugs were developed based on the bottom-up with middle-out techniques (Figure 2

ChEMBL v34 compound record for TIRZEPATIDE (CHEMBL4297839): max_phase 4 (approved), first_approval 2022, parenteral, GIP receptor agonist, first-in-class, black-box warning flag