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It is worth noting that histological examination of the liver revealed no significant liver inflammation in either WT or KO mice (Fig

Microscopically, the group treated with boswellic acid indicated an intact cellular framework along with no apparent signs of inflammation, showing the potent anti-inflammatory activity of boswellic acid

Importantly, combined inhibition of GCLC, GLS and CAD is synthetically lethal and induces tumor regression by abrogating GSH and nucleotide biosynthesis in preclinical GBM models in vivo