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Because OS directly promotes neurodegeneration in flies 26 and mice 16 , LLCs may be a missing link underlying observations that age-related increases in OS are exacerbated by disruption of circadian clocks 8,14 , and that clock mutations accelerate OS-induced neurodegeneration in aging flies 15 and mice 16

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[21] The activity of GSI-type enzyme is controlled by the adenylation of a tyrosine residue