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Although PYC has been shown to reduce CRP levels, existing trials are limited by small sample sizes (e.g., five studies totaling approximately 324 participants in a CRP meta-analysis), high heterogeneity (I 2 99%), and variability in dosing regimens, treatment duration, and study populations ( Similarly, although PYCs anticancer effects have been demonstrated in multiple cell lines and preclinical models, translational data remain limited

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J Comput Aided Mol Des 31:201211 Lolok N, Sumiwi SA, Muhtadi A, Susilawati Y, Hendriani R, Ramadhan DS, Levita J, Sahidin I (2022) Molecular docking and molecular dynamics studies of bioactive compounds contained in noni fruit Morinda citrifolia L

The cysteine residue in the molecule center is liable for the high reduction potential of GSH