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GLP-1 (glucagon-like peptide-1) receptor agonists are a class of prescription medications originally developed for type 2 diabetes that have been shown to produce significant weight loss

Not only does this bottleneck starve the cell of ATP, but the accumulating MMA is highly neurotoxic

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In some ways, the lesser degree of obesity and exacerbated metabolic disturbances in these mice resembles the clinical characteristics of Asian patients with T2DM 17,18 , suggesting that Insr P1195L/ +/HFD mice are suitable for investigating the pathophysiology of HFD-sensitive T2DM in humans