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Recently, despite a lack of significant association between hyperhomocysteinemia and the risk of venous thromboembolism, in a prospective study of patients with systemic lupus erythematosus, Petri et al (1996) report that hyperhomocysteinemia, defined as total plasma homocysteine concentrations higher than 14.1 mol/L, is significantly associated with arterial thrombotic events (odds ratio 3.74), and stroke (odds ratio 2.24)