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Since V max and K m are constants, the rate is directly proportional to the concentration, which is the definition of first-order kinetics

188,189 Despite this, the primary focuses in the development of anti-inflammatory drugs are appropriate intervention timing and enhancing target specificity

When the antioxidant defense system fails to effectively eliminate ROS, these oxidants accumulate precipitously (100), leading to elevated intracellular oxidative stress, which subsequently triggers cuproptosis