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In some cases, users may also experience an inflamed or swollen tongue, a burning or prickling sensation in the arms or legs, and a stuffy nose

In the case of animals inoculated peripherally with scrapie, the agent propagates along peripheral sensory and autonomic nerves in the peritoneum to enter the spinal cord and medulla, and then ascends to invade the brain (Kimberlin and Walker, 1982)