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This has not been widely studied, but cell culture models are generally undertaken at ~20% environmental oxygen, and isolated muscle tissue models use protocols that involve predominantly bubbling of bathing solutions with 95% oxygen-5% carbon dioxide, although the oxygen environment of muscle cells at rest in vivo is much less oxygen rich and appears to be between 2 and 10% (81, 367)

Adverse Effects Most participants in the study reported overall improvements in their children

In short, this article validates an innovative and promising strategy to control the action of PROTACs, in which introducing cleavable groups under certain physiological conditions helps to increase selectivity and consequently reduce off-target effects of PROTACs 118