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doi: 10.1172/jci144201 108 CuhadarUGentryCVastaniNSensiSBevanSGoebelAet al

Activation of the Notch pathway increases RORt transcription and Th17 cell responses [39]

R This pathway is unique for two reasons: The initial activation step occurs in mitochondria via acyl-CoA ligases that require acetyl-CoA (specifically ATP, CoA, and the carboxylic acid substrate form an acyl-CoA intermediate)