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In some individuals, usually adults, acetaminophen can induce a high-anion-gap metabolic acidosis secondary to 5-oxoproline (ie, acquired pyroglutamic academia), possibly because of a genetically determined propensity (54

In a mouse model of pulmonary fibrosis exposed to PM2.5 [184], reduction of ALKBH5 activated the pro-fibrotic signaling pathway YAP, which subsequently increased the expression of P4HA2

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