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TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination

Therefore, depletion of NADPH stores in G6PD-d has the potential to both limit the production of ROS by NOX family enzymes, while simultaneously expediting the accumulation of ROS from non-NADPH-dependent sources, such as the mitochondrial electron transport chain, peroxisomal -oxidation, oxidative protein folding, and other cytoplasmic enzymes (xanthine oxidase, cyclooxygenase, lipoxygenase) 95,96

Conclusion: We demonstrate through multiple lines of evidence that the LPAR/PI3K/AKT axis is vital for the activation of YAP and hepatic fibrogenesis due to HIV infection

10.1016/j.archger.2022.104895 100 SaxamiG.KerezoudiE