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Name: acetyl l carnitine depression mechanism of action Acetyl-L-carnitine in chronic pain: A narrative review Frontiers | Carnitine and Depression
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Frontiers Carnitine and Depression L Carnitine in Mitochondria Encyclopedia MDPI Acetyl L carnitine physical chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression Molecular Psychiatry The effects of pharmacologically decreased availability of L carnitine Download Scientific Diagram

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If a severe imbalance occurs between pro-apoptotic and anti-apoptotic proteins on the mitochondrial membrane, it can lead to mitochondrial depolarization and MOMP, ultimately activating the mitochondria-dependent apoptosis pathway [45]

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To increase the specificity of ABT263, the proteolysis-targeting chimera (PROTAC) platform was used for modification to generate three dual BCL-xL and BCL-2 inhibitors, PZ15227, 374 753b, 375 and WH244