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By directly binding to SLC7A11, recombinant human autophagy effector protein (BECN1) inhibits the activity of system x c , promotes GSH consumption and lipid peroxidation, and induces ferroptosis in cancer cells [137]

doi: 10.1210/edrv.23.1.0455 10 BishtN.PhalswalP.KhannaP

Updated February, 2008

In pathophysiological states, including increased insulin resistance, the hybrid receptor number is changed significantly, thus potentially abrogating the chance for IGF-1 to alter glucose metabolism [129, 132, 133]