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Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or homeopathic supplement, or using any treatment for a health problem

A large number of studies also demonstrate its positive impact on overall health and well-being

However, the success of this treatment in solid tumors has been challenged by the tumor-antigen heterogeneity, impaired CAR-T cell trafficking and infiltration, and the presence of an immunosuppressive tumor microenvironment (TME) [6]

One of the key regulators of this response is the transcription factor hypoxia-inducible factor (HIF) (55)