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Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

While its physiological functions include maintaining immune surveillance and tissue homeostasis, aberrant activation is a hallmark of numerous cancers [5]

However, on the TNF flow cell surface, all dosed subjects in cohort 7 showed increasing signal compared to baseline which was confirmed with the anti-human IgG reagent, but not the AMG 966-specific antibody 1A3, indicating these subjects developed endogenous anti-TNF antibodies as a result of AMG 966 treatment ( Figures 8F, H )

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