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The effectiveness period of these injections varies based on individual factors and metabolism rates, and may last between one to two weeks in the system [12]

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In addition, exogenous IGF-1 administration has been shown to reduce serum glucose levels [95, 143, 144], not only in healthy individuals [140, 145147], but also in those with insulin resistance [148, 149], type I [150152], and T2D [153155]

The A-side buffer contained 100 M Lucifer yellow dye, in transport buffer (1.98 g/L glucose in 10 mM HEPES, 1 Hanks balanced salt solution, pH 7.4), and the B-side buffer was transport buffer at pH 7.4