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4 Interplay between mitochondrial dysfunction and fatty acid metabolic disturbances in the failing heart Mitochondrial dysfunction and FAO disorders reinforce each other in the failing heart: ETC defects and m loss suppress FAO, while dysregulated FAO promotes oxidative stress, lipotoxicity, and structural damage, further compromising mitochondrial function

Am J Respir Crit Care Med 157(3 Pt 1):762768

Our results align with previous reports showing that numerous drug-metabolizing enzymes and transporters are downregulated in septic mice and pigs (72, 73)

Pneumonia Bacterial pneumonia, such as that caused by Pseudomonas aeruginosa , can impair synaptic plasticity in hippocampal neurons via Tau-dependent mechanisms, leading to cognitive deficits [3, 25, 26]