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The successful trapping and characterization of sulfenic acid intermediate in EgtE catalysis provide evidences supporting the involvement of ergothioneine sulfenic acid as a key intermediate when ergothioneine is exposed to oxidative conditions as suggested by Servillo et al

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168 A large meta-analysis of 65 randomized controlled trials with 7,887 hypertensive subjects found folic acid plus blood pressure-lowering medication was more effective than medication alone for lowering blood pressure, lowering homocysteine levels, and reducing risk of cardiovascular events and stroke by 13% compared with control groups