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The endpoints included the oxidative stress marker thiobarbituric acid-reactive substances (TBARS), plasma osteopontin (OPN), plasma paraoxonase (PON1) activity, H&E histology, gadolinium-enhanced magnetic resonance imaging (MRI) of leg muscle and motor functional measurements

These patients can quickly enter in a state of shock involving hyperactivation of the immune system and hypercoagulation in small blood vessels [61, 62]