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In a rat model simulating SAM conditions, ~ 24% of hepatic genes were differentially expressed with upregulation of TRIB3 and FGF21 (markers of disrupted hepatic signaling) and long-lasting steatosis was attributed to peroxisome loss via transcription-mediated pexophagy [137]

It has been shown to improve outcomes in patients with sepsis, acute respiratory distress syndrome (ARDS), and certain types of cancer

Summary of Common Reactions: MedicineNet notes that frequent side effects include fluid retention, weight gain, hypertension, low potassium, headache, muscle weakness, easy bruising, acne, glaucoma, cataracts, growth retardation in children, and psychiatric disturbances

Gut Microbes 13(1):1946366 Yuksel M et al (2016) The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model