glutathione peroxidase role in liver detoxification Frontiers The Role of Oxidative Stress

This is whats activated when you do a keto diet, or especially when you fast

The major reason that I havent discussed this master antioxidant lately is that there has been a question regarding the biochemistry of glutathione in some studies

Experimental studies utilizing HD mouse models have demonstrated that inhibition of ferroptosis can prevent degeneration of spinal motor neurons and enhance motor function, thereby establishing a direct connection between the occurrence of ferroptosis and the advancement of HD (Chen et al., 2015)

On the other hand, a significant increase in TDO expression has been found in preeclampsia, but since inflammatory response is involved in the pathogenesis of preeclampsia, it can be hypothesized that upregulation of TDO cannot fully compensate for the decrease in IDO in this regard