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220 HIF-1 interacts with BCL2, BNIP3, BNIP3L/NIX, Beclin-1, ATG proteins, and PIK3C3 to stimulate autophagy, 221,222 while AMPK and PTEN suppress mTORC1, activating ULK1 and enhancing autophagosome-lysosome fusion

Patients with hepatocellular carcinoma which progresses to cancer cachexia often exhibit accompanied chronic liver inflammation, which is one of the major factors leading to poor prognosis (26)

Second, the controlled injury stimulates fibroblasts, the cells responsible for producing new, healthy collagen

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