glutathione reductase removal of reactive oxygen species (ROS) by an antioxidant defense Reactive oxygen species generation and

Notably, deletion of GPX4 caused severe phenotypic abnormalities in mice in animal experiments, whereas deletion of the ALOX12 gene did not cause major developmental defects in mice

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This has accelerated research into copper-targeting therapies, with numerous studies on copper chelators and ionophores demonstrating significant therapeutic efficacy across various cancer types (Table III)

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