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PCSK9 knockout in apoE/ mice fed a Western diet (21% fat and 0.2% cholesterol) for 6 months reduced the IMT of valves, the root, the ascending aorta, and the brachiocephalic artery (BCA) by 25%, 18%, 9%, and 0%, respectively, but did not change TC levels [162]

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Integrative constraint-based modeling and proteomics uncover astrocytic metabolic adaptations to the post-TBI microenvironment