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Moreover, active efflux transporters, such as breast cancer resistance protein (BCRP), P-glycoprotein (P-gp), and multidrug resistance-associated proteins (MRPs), expel many therapeutic agents from the endothelial cells back into the bloodstream, significantly reducing their CNS infiltration 69,70

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After patients with sepsis were cured and discharged, systemic organs were still in a state of immunosuppression for a long time, and such patients were more likely to have secondary severe pulmonary infection (203).The suppression of pulmonary innate immunity induced by sepsis is mediated by IRAK-M molecules