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Berberine can significantly decrease lipid accumulation, ameliorated reactive oxygen species (ROS) and lipid peroxides, TNF, and phosphorylation of NF-B p65 both in MCD mice and in AML12 cells induced by MCD/LPS or PA [124]

Similar to our findings in the mouse model, the severity of human CL correlated with elevated eosinophils counts in the blood and in the skin lesions (Salaiza-Suazo et al, 2024)

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Additional Predictors Factors like preceding Campylobacter jejuni infection , bulbar symptoms, facial weakness, and autonomic dysfunction correlate with more severe disease courses