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Of note, neuroinflammation has furthermore been implicated in the pathophysiology of depression [87], whereas increased inflammatory markers, such as C-reactive protein (CRP) or interleukin-2 (IL-2), have been specifically described to be more associated with the atypical subtype of depression [69]

Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples

The only problem is that the inhibitor has a relatively short retention time in the body: its too small and the kidneys would filter it out