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The studies by Doll et al (87) and Bersuker et al (88) report that CoQ10 can behave as a lipophilic free radical-trapping antioxidant that diminishes the accumulation of lipid peroxides and attenuates the occurrence of ferroptosis

The inhibitor of glutamine synthetase (GS) activity, l-methionine sulfoximine (MSO), has been shown to inhibit glutamine metabolism, induce a shift to M1-TAMs, and act as a potent antitumor immunity [123]

Chronic IFN-I stimulation perturbs lipid metabolism and redox balance in exhausted CD8 + T cells, leading to aberrant lipid accumulation and elevated lipid peroxidation, which exaggerates metabolic and functional exhaustion of T cells (46)

Smith, Andy J