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As has been discussed above, some organisms (especially pathogens) seem to be able to withstand high levels of amino acid misincoporation, or even be able to dispense of the editing function altogether, making the editing a less promising target

10.1002/mnfr.201700447 7 BeekmannK.RubiL.DE HaanL

Factors influencing APAP-related hepatotoxicity The most essential determining factor in both the development and severity of APAP hepatotoxicity is the drugs ingested dose, but some argue that the length of time from APAP ingestion to N -acetylcysteine (NAC) therapy (time to NAC) is equally if not more important

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