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At low intracellular concentrations (0.011 M), H 2 S injects electron equivalents into the mitochondrial electron transport chain (mETC) by reducing quinone to quinol via sulphide:quinone oxidoreductase (SQR), ultimately stimulating ATP production

Cells were then washed with PBS and media replaced with low nutrient media where 2 mM glucose was substituted with equimolar concentration of 13 C-labelled glucose (D-glucose, CK Isotopes) and DMSO (0.003% v/v) control and FOXO1 inhibitor (1 M) were replenished for further 12 h until extraction

Although UAA incorporation has enormous promise, it is also in its infancy and significant hurdles are currently being addressed

Acquired pharmacological resistance elevates the chance of recurrence (Hellinger et al