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Description

Efficacy of melatonin for chronic insomnia: systematic reviews and meta-analyses

Supernatant was collected

Weeks 13-16: About 14 mg used at 500 mcg/day

Phase (approx.) Cagrilintide dose Frequency Weeks 14 0.25 mg Once weekly Weeks 58 0.5 mg Once weekly Weeks 912 1.0 mg Once weekly Weeks 1316 1.7 mg Once weekly Week 17 onward 2.4 mg (max studied) Once weekly This step-wise schedule mirrors the titration used in cagrilintide and CagriSema studies ( Lau et al., Lancet 2021