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It integrates signals from diverse extracellular stimuli, including growth factors, hormones and nutrients, to coordinate critical cellular responses necessary for maintaining homeostasis (106108)

This upregulation was further enhanced in the AMAN model (Fig

Thus, due to the nature of the original diagnostic criteria for GHD, and the reticence to consider aging a disease per se, even though disease risk, incidence and severity can be attributed at least in part to declining activity of the GH neuroendcrine axis, the criteria for determining if secretagogue therapy is indicated as an intervention in aging, are less stringent than those promulgated by Endocrine Society guidelines

PMID 22787590