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PAH was the first enzyme to be discovered to have BH4 as a mandatory cofactor for the hydroxylation of Phe

Oxidative stress, caused by xenobiotics, can deplete glutathione reserves and other low molecular weight thiol-containing compounds (Lushchak, 2011[27])

In contrast, E2 core antigens lacking the HVR1 have shown promising results in immunogenicity studies and are alluring antigens for epitope-focused vaccine strategies 22,24

Other key areas of work include continuing to ensure the Council has adequate insurance arrangements in place, providing advice and support in relation to insurance related queries and acting as a point of escalation in regards to any claims