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Su C, Cunningham RL, Rybalchenko N, Singh M (2012) Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling

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Although osteoarthritis is the most common condition causing knee pain, there many other causes of joint pain, such as ligament injuries, tears of the meniscus (the shock absorbers of the knee), infection, nerve conditions, and immune disorders

Reduction of Reactive Oxygen Species (ROS): This peptide has been shown to prevent and treat gastrointestinal inflammation by decreasing the production of reactive oxygen species, thereby protecting the GI tract from oxidative damage