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Additionally, adrenaline, which induces cAMP elevation and triggers calcium release from the endoplasmic reticulum, stimulates higher magnitude of calcium oscillation in GCGR-KO cells, indicating increased calcium release from the endoplasmic reticulum

Concluding and further perspectives Ferroptosis is a Fe 2+ -dependent, lipid peroxide accumulation-triggered form of cell death that is closely related to the occurrence, development, and drug resistance of tumors