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Evid Based Complement Alternat Med 2020:18

Primary Handling Editor: Yanina-Yasmin Pesch and Isabella Samuelson, in collaboration with the Nature Metabolism team

In general, Immune responses play a crucial role in the occurrence and development of ALD and the main mechanisms are shown in Figure 3

It does not bind classical retinoic acid receptors (RARs) the way retinoids do, which is why it carries none of retinol's photosensitivity or purging risk