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Retrieved August 12, 2022 from Acknowledgements We thank Chris James and Philip Wong for their oversight of the bioanalytical methods, Manpreet Virk and Valerie Kramlinger for carrying out select in vitro phenotyping experiments, Brooke Rock for guiding the proteomics experiments and supporting data analysis troubleshooting, and Marintan Spring and Shauna Hutton for their support in the preparation of this manuscript and contributions to the PK analysis and clinical study report during the conduct of the study, respectively