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Endotoxins and Detoxification Mechanisms Endotoxins are produced by certain bacteria in the gut, especially gram-negative bacteria, and can enter the bloodstream when the gut lining is compromised

This study demonstrated that shikonin exerted a significant protective effect against ouabain-induced SGNs injury

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In conclusion, our study revises the traditional view of GSH as a global protective antioxidant against protein oxidation under physiological condition and demonstrates that GSH depletion through enhanced degradation leads to selective protein oxidation