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For example, in human PAECs under hypoxic conditions, the levels of ROS were increased, while the levels of mitochondrial thioredoxin 2, an antioxidant protein, were reduced which could contribute to exacerbating hypoxia-induced ROS production [157]

The -glutamyl moiety of the donor molecule is bound to the active site at the bottom of the pocket by an extensive network of hydrogen bonds and salt bridges formed mainly with the residues present in the small subunit (Okada et al., 2006)

[] However, PGC-1 is not an ideal target because its biological activity must be regulated within a very narrow and precise range

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