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Description

An Amino Acid-based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA

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Thomson PJ, Illing PT, Farrell J, Alhaidari M, Bell CC, Berry N, et al

Under reaction conditions of pH 5, 1 h and 80 C, RCYs were determined to be 100 0.0%, 91.6 0.4%, 72.2 6.3%, 43.3 10.1% and 3.9 2.7% ( n = 3) for ligand concentrations of 10 4 , 10 5 , 10 6 , 10 7 , and 10 8 M, respectively