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The Hp1/2 proteins form different oligomers, such that a dimeric Hp11 molecule can bind two haemoglobin dimers, while the polymeric Hp21 and Hp 22 molecules have the capacity to bind greater numbers of haemoglobin dimers (Morton et al., 2006)

These evaluations support accurate diagnosis, help track baseline status, and allow clinicians to monitor progress throughout the course of peptide therapy, ensuring that treatment remains safe, appropriate, and effective over time

Current evidence is mixed and limited