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The NHS access journey, should CagriSema receive approval, would then follow a separate NICE appraisal process the same pathway that Wegovy and Mounjaro have navigated

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways

The peptide stimulates expression of early growth response 1 (EGR-1) gene, which regulates cytokine and growth factor generation along with early extracellular matrix formation, while simultaneously inducing its repressor NAB2 to prevent excessive angiogenic signaling