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These limitations are particularly critical in AKI, where therapeutic windows are narrow, disease progression is rapid, and off-target systemic exposure may exacerbate adverse effects

The powerful combination of all-trans-retinal and triptolide, contained within inflammation-targeted nanoparticles meticulously crafted to target macrophages with precision, exhibits an impressive capacity to significantly reduce the infiltration of CD3+ T cells and F4/80 macrophages

Almost a third of patients had a significant reduction in both pain and either fatigue or sleep with LDN, versus only 11 percent with placebo

Front Immunol 15 (2024)