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This particular feature has an important role in PD as several drugs have limited ability to cross the BBB on their own (123)

Regrettably, more studies are necessary to validate how oxidase inhibitors impact ferroptosis

Notably, NO and its derivatives (e.g., nitrite and nitrate) are more stable and less susceptible to rapid degradation under the antioxidant systems of serum 37 .The enzymatic antioxidants, including GPX, CAT, SOD and thioredoxin reductase (TrxR), play key roles in mitigating oxidative stress induced by ROS and free radicals 38

In addition, the increased dose of arsenic trioxide (0.5 mg/kg) in combination with idarubicin and cytarabine was safe and well tolerated in newly diagnosed AML patients