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In animal models, overexpression of ANGPTL6 is associated with increased energy expenditure, protection of hepatic steatosis, resistance to high-fat diet-induced overweight, and increased insulin sensitivity compared with controls

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Phase 3 trials of tirzepatide did not exclude participants taking antioxidant supplements, and subgroup analyses showed no difference in adverse events or efficacy between supplement users and non-users

Iron dosage For immunofluorescence staining, cells were plated and grown in the appropriate medium supplemented with 2% FBS 24 h before being treated as indicated