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These findings align with recent evidence that modulation of BBB transport mechanisms can rapidly enhance A removal and improve functional outcomes in AD models 25

More help Overall Assessment of the AOP Addressess the relevant biological domain of applicability (i.e., in terms of taxa, sex, life stage, etc.) and Weight of Evidence (WoE) for the overall AOP as a basis to consider appropriate regulatory application (e.g., priority setting, testing strategies or risk assessment)