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Phosphorylation of IGF-IR/InsR is elevated in ER+ breast cancer cells resistant to estrogen deprivation and tamoxifen, possibly due to increased secretion of IGF1/2 in these cells and elevated expression of retinoblastoma-binding protein 2 that inhibits IGFBP4/5 by interacting with ER-NRIP1-HDAC1 complex [107,108,109]

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It helps to neutralize and eliminate toxins, free radicals, and other harmful substances from the body, particularly in the liver

Serum folate was statistically correlated with reduced all-cause mortality in the fourth and third quartiles of the young and middle-aged groups, respectively ( Table 3 )